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By Klaus Ley

Inflammatory mobilephone recruitment calls for the concerted motion of no less than 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate buildings serving as selectin ligands, and sure ectoenzymes. This quantity provides a accomplished evaluate at the such a lot appropriate leukocyte and endothelial adhesion molecules. The chapters are written via leaders within the box and concentrate on the biology, constitution, functionality, and law of adhesion molecules. at present authorized adhesion molecule-based treatments are reviewed and an outlook for destiny ways is usually provided.

The publication is of curiosity to clinicians and scientists from immunology, body structure, melanoma examine, rheumatology, allergology, infectious illnesses, gastroenterology, pulmonology and cardiology.

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Cleavage of L-selectin results in the generation of a large soluble extracellular fragment, sL-selectin, and a small ~6-kDa cell-associated fragment containing the transmembrane and cytoplasmic domains [14]. Consistent with the above-noted size differences in cell-associated L-selectin, two major isoforms of sL-selectin are found within human serum: a lymphocyte-derived ~62-kDa form and a neutrophil-derived 75–100-kDa form [5]. Both lymphocyte- and neutrophil-derived forms of sL-selectin have also been described in mouse [6] and rat [18] serum.

Blood 102: 2060–2067 Hidalgo A, Weiss LA, Frenette PS (2002) Functional selectin ligands mediating human CD34+ cell interactions with bone marrow endothelium are enhanced postnatally. J Clin Invest 110: 559–569 Xia L, McDaniel JM, Yago T, Doeden A, McEver RP (2004) Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood 104: 3091–3096 Hidalgo A, Frenette PS (2005) Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow.

Furthermore, the presence of sL-selectin in the serum may establish a threshold level for L-selectin ligand expression that is required for leukocyte migration. In addition to the generation of a functionally active soluble receptor, L-selectin cleavage has been proposed to be involved in the regulation of leukocyte/endothelial cell interactions. This idea is supported in part by the finding that leukocytes show decreased L-selectin expression following interaction with, or migration through, the endothelium [21–23].

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