Download Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee PDF

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By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Offers a file from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending examine to shut major gaps in current wisdom of prion ailments and strategies for strengthening the U.S. examine infrastructure for learning those ailments. Softcover. DNLM: Prion ailments, prevention & control--United States.

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Additional info for Advancing Prion Science: Guidance for the National Prion Research Program

Sample text

If prion aggregates are the infectious agent that causes TSEs and if a prion is the misfolded protein known as PrPSc, then by parallel reasoning, aggregates of PrPSc are the infectious agent of TSEs. However, some reputable TSE experts believe that PrPSc alone may not be sufficient to cause a TSE infection, although the protein may be associated with and even necessary for such infection. A number of these investigators hypothesize that the infectious particle—the prion—may contain hidden nucleic acid, additional proteins, or some other additional, essential material.

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Ten great public health achievements in the 20th century. Morbidity and Mortality Weekly Report 48(12):241–244. CWD Task Force. 2002. Plan for Assisting States, Federal Agencies, and Tribes in Managing Chronic Wasting Disease in Wild and Captive Cervids. [Online]. html [accessed March 24, 2003]. Enari M, Flechsig E, Weissmann C. 2001. Scrapie prion protein accumulation by scrapieinfected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proceedings of the National Academy of Sciences of the United States of America 98(16):9295–9299.

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