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By Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens

African horse disorder virus is a double-stranded RNA virus which explanations a non-contagious, infectious arthropod-borne ailment of equines and sometimes canine. 9 targeted, the world over recognized serotypes of the virus have to this point been pointed out. This ebook relies upon the findings of 2 programmes funded through the eu fee. it is going to be of worth not just to the professional examine staff but in addition to veterinary employees facing regulate and to legislators trying to advertise secure overseas move of equines. the subjects coated comprise cutting-edge discussions on diagnostics, vaccines, molecular biology, vector reports, and epidemiology.

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Laviada4, and C. K. Summary. Two groups, comprising 4 donkeys and 4 mules (group 1) and 4 donkeys and 3 mules (group 2), were used to determine the duration of viraemia and to monitor the development of antibodies following inoculation with African horse sickness virus (AHSV). One group of animals was given a single dose of attenuated AHSV serotype 4 (AHSV 4) vaccine. The second group was inoculated with a virulent field strain of AHSV 4. Both groups were subsequently challenged with the virulent field strain of AHSV 4, 51 and 58 days, respectively, after their primary inoculation.

The gross pathological changes were similar in both ponies and included generalised oedema between the fascial planes particularly in the neck and around the oesophagus, straw coloured pleural and pericardial effusions, interlobular oedema and petechial haemorrhages on the epicardium and endocardium of the interventricular septum, the left ventricle and the atrio-ventricular valves. Additional findings in P2 included haemorrhages on the serosal surface of the small intestine and Table 2. N. 7 NVD NVD NVD NVD NVD NS NVD NS a Blood Log lO Egg LD50/ml; dpi days post infection; ELISA titre LoglO/gm; MLDso Log lO Mouse LD50/gm; NT not tested; NVD no virus detected at 10-1 dilution; - no antigen detected in 20% homogenised tissue suspension; NS no sample 42 C.

The animals were then observed for 35 days after the first injection of cyclophosphamide. The 3 donkeys in the second group were given the same regime of cyclophosphamide at the same time as the first group and only subsequently were infected with a similar dose of AHSV-4. Observation also continued for a further 35 days. Clinical examination The temperature of each donkey was taken twice daily throughout the experiment and a full clinical examination was carried out each day. Virus isolation from the donkeys Group 1 donkeys: Whole heparinised blood samples were taken daily from each donkey for 30 days after infection and then at approximately weekly intervals for the duration of the experiment (125 days).

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