By Donna H. Wang
Donna Wang and a panel of hands-on specialists describe in step by step element all of the significant molecular, biochemical, and useful concepts now utilized in probing the renin-angiotensin process. those diversity from using embryonic gene focusing on to create of mutant traces, to the practical research of parts of the renin-angiotensin method. entire and hugely useful, Angiotensin Protocols interprets professional wisdom into without problems reproducible tools that let all biomedical investigators effectively to discover the function of angiotensin in overall healthiness and illness at the present time.
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Extra info for Angiotensin Protocols (Methods in Molecular Medicine)
H. and Ramirez, A. (1998) TGF-beta- and angiotensin-II-induced mesangial matrix protein secretion is mediated by protein kinase C. Nephrol. Dialysis Transplant. 13, 2804–2813. 27. Ruiz-Ortega, M. and Egido, J. (1997) Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int. 52, 1497–510. 28. , and Kubo, T. (1999) Evidence for the involvement of platelet-derived growth factor in the angiotensin II-induced growth of rat vascular smooth muscle cells.
Interest in this peptide initially stemmed from the observation of Brazilian scientist Sergio Ferreira that it inhibited kinin-destroying enzymes; for this reason it was first named bradykinin-potentiating peptide (BPP) (59). It was then discovered that ACE and plasma kininase II are the same enzyme and that BPP was effective in inhibiting the conversion of Ang I to Ang II (60). Elucidation of the structure of BPP (teprotide) and its synthesis was performed by researchers at the Squibb Institute for Medical Research in Princeton, NJ, who also made this compound available for basic and clinical research (61).
Nephrol. 9, 224–230. 36 Laffer and Elijovich 23. Goyal, R. , Satia, M. , Bangaru, R. , and Gandhi, T. P. (1998) Effect of long-term treatment with enalapril in streptozotocin diabetic and DOCA hypertensive rats. J. Cardiovasc. Pharmacol. 32, 317–322. 24. , et al. (1999) Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis. Kidney Int. 55, 877–889. 25. , Ziyadeh, F. , and Stahl, R. A. (1996) Angiotensin II is mitogenic for cultured rat glomerular endothelial cells.