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Proteases are enzymes that basically "eat" protein. with out proteases, infectious organisms can't appropriately mount an assault opposed to a bunch. it really is therefore that proteases became renowned pursuits for drug discovery. study has proven that for those who can inhibit the protease, you could shield opposed to the invading microbe.
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Clin Infect Dis 2004;39: 31–37. Infections with Organisms Producing Extended-Spectrum β-Lactamase 33 89 Zanetti G, Bally F, Greub G, et al: Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized study. Antimicrob Agents Chemother 2003;47:3442– 3447. 90 Roussel-Delvallez M, Sirot D, Berrouane Y, et al: Bactericidal effect of beta-lactams and amikacin alone or in association against Klebsiella pneumoniae producing extended spectrum beta-lactamase.
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131 Perlroth J, Kuo M, Tan J, Bayer AS, Miller LG: Adjunctive rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature. Arch Intern Med 2008;168:805–819. 132 Barrett JF: Recent developments in glycopeptide antibacterials. Curr Opin Investig Drugs 2005;6: 781–790. 133 Schmidt-Ioanas M, de Roux A, Lode H: New antibiotics for the treatment of severe staphylococcal infection in the critically ill patient. Curr Opin Crit Care 2005;11:481–486. 134 Van Bambeke F: Glycopeptides in clinical development: pharmacological profile and clinical perspectives.