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Binding of IL-5 in conjunction with other signals that are not well understood induces differentiation of the dividing B cells into plasma cells and memory cells. Plasma cells are highly specialized to secrete large amounts of antibody. 5 B-cell differentiation. 46 CHAPTER 4 plasma cells is devoted to the production of antibodies. They are terminally differentiated and live for only approximately 3- 4 days, primarily in the lymphoid organs. B memory cells are long-lived cells that do not secrete antibody but retain cell-surface antibody as their specific antigen receptor.

E. Max, and P. Leder. 1979. A K-immunoglobulin gene is 20 CHAPTER 2 formed by site-specific recombination without further somatic mutation. Nature 280:370-375. G. Seidman, and P. Leder. 1979. Sequences of five potential recombination sites encoded close to an immunoglobulin K constant region gene. Proc. Natl. Acad. Sci. 76: 3450-3454. , A. H. Edgell, F. M. C. Tiemeier, and P. Leder. 1978. Multiple related immunoglobulin variableregion genes identified by cloning and sequence analysis. Proc. Natl.

M. C. Tiemeier, and P. Leder. 1978. Multiple related immunoglobulin variableregion genes identified by cloning and sequence analysis. Proc. Natl. Acad. Sci. 75:3881- 3885. , L. Gatmaitan, E. Loh, J. Schilling, and L. Hood. 1978. Rearrangement of genetic information may produce immunoglobulin diversity. Nature 276:785-790. , H. Huang, M. Davis, K. Calame, and L. Hood. 1980. An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and Jw Cell19: 981-992. , K.

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