By Ambikanandan Misra, Aliasgar Shahiwala
Use of polymers has develop into essential within the box of drug supply. Polymers play a vital position in modulating drug supply to use greatest healing advantages and feature been basic within the winning improvement of a number of novel drug supply structures which are now available.
This ebook offers information of the functions of polymeric drug supply structures that would be of curiosity to researchers in industries and academia. It describes the improvement of polymeric structures starting from the normal dosage varieties as much as the newest clever platforms. The regulatory and highbrow estate points in addition to the medical applicability of polymeric drug supply platforms also are discussed.
Each varied drug supply direction is mentioned in a separate bankruptcy of the e-book. All significant routes of drug supply were coated to supply the reader with a breathtaking in addition to an in-depth view of the advancements in polymer-based drug supply structures. Appendices are incorporated which include priceless pharmaceutical homes of the polymers and critical polymeric purposes for numerous drug supply routes.
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Extra info for Applications of polymers in drug delivery
23 Applications of Polymers in Drug Delivery The bilayered tablets are formulated in four steps. First a tablet is made by compression of L-HPC and lactose or stearic acid (first layer), which is then compressed along with a mixture of the drug and crystalline cellulose (second layer). The bilayered tablet is then coated with a solution of EC and micropores are formed either mechanically or by laser on the first layer. Finally, tablets are sugar coated . 3 Pressure Controlled System In the large intestine, the contents are moved from one part to the next, as from the ascending to the slanting colon by forcible peristaltic movements commonly termed as mass peristalsis .
For rapid release of water insoluble drug effervescent or disintegrating agents are added. , polymethacrylates). , HPMC, PVA). , glyceryl monooleate). , pectin). 3 Ion-Exchange Based Drug Delivery System Ion exchange resins are insoluble polymers that contain acidic or basic functional groups and have the ability to exchange counter-ions within aqueous solutions surrounding them. An ion exchange resin is an insoluble matrix normally in the form of small beads of 1-2 mm diameter, usually white or yellowish, fabricated from an organic polymer substrate backbone .
A mathematical model for drug release properties of polymer coated ion-exchange resin complex has also been derived. For example, polymer (polyvinyl acetate) 25 Applications of Polymers in Drug Delivery coated dextromethorphan-resin complexes have been explored for studying release characteristics by considering diffusion, swelling, and ion exchange processes . 2 Transdermal Drug Delivery System Research in the field of polymer science has paved the way for transdermal delivery system designs that have considerable flexibility.