By Andrea Borini, Maria Valeria Savasi
This concise and functional publication is the 1st of its sort to envision using assisted reproductive applied sciences (ART) relating to blood-borne infectious ailments: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The ebook opens with a dialogue of the effect of those viruses on female and male fertility, by way of particular chapters of every of them, together with paintings with HIV and HCV serodiscordant (where both the male or girl is optimistic) and the detection and influence of HBV and HCV in human gametes and embryos. an immense personality on laboratory security while acting artwork with blood-borne viruses follows, and the booklet concludes with a dialogue of paintings in austere and resource-poor settings, the place those infections are usually dominant because of loss of remedy and entry to vaccines. Written and edited by way of a global array of specialists in reproductive drugs, Assisted Reproductive applied sciences and Infectious ailments explores questions, strategies, and similar concerns with the purpose of successfully supporting clinicians operating with serodiscordant wishing to have childrens.
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Extra resources for Assisted Reproductive Technologies and Infectious Diseases: A Guide to Management
This codon stops the expression of the e protein, which is processed to produce HBeAg . However, HBV DNA synthesis persists and may cause liver damage, with progression to cirrhosis and cancer. Loss of HBeAg expression can also occur with mutations in the basal core promoter (BCP) region that regulates the expression of both HBeAg and core protein . These mutations have been associated with fulminant hepatitis and severe chronic liver disease [15, 16]. However, fulminant hepatitis can occur in the absence of such mutations [17, 18].
2004;18(10):1353–62. 5. Anderson DJ, et al. White blood cells and HIV-1 in semen from vasectomised seropositive men. Lancet. 1991;338(8766):573–4. 6. Nuovo GJ, et al. HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization. Am J Pathol. 1994;144(6):1142–8. 7. Bagasra O, et al. Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men. AIDS. 1994;8(12):1669–74. 1 The Impact of Human Immunodeficiency Virus… 23 8. Scofield VL, et al.
25. Ping LH, et al. Effects of genital tract inflammation on human immunodeficiency virus type 1 V3 populations in blood and semen. J Virol. 2000;74(19):8946–52. 26. Crittenden JA, Handelsman DJ, Stewart GJ. Semen analysis in human immunodeficiency virus infection. Fertil Steril. 1992;57(6):1294–9. 27. Krieger JN, et al. Fertility parameters in men infected with human immunodeficiency virus. J Infect Dis. 1991;164(3):464–9. 28. Muller CH, Coombs RW, Krieger JN. Effects of clinical stage and immunological status on semen analysis results in human immunodeficiency virus type 1-seropositive men.