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By John W. Corcoran (ed.)

The sequence on Antibiotics produced through Springer-Verlag begun greater than a decade in the past with the approximately simultaneous visual appeal of 2 volumes, one facing the mode of motion of antibiotics and the opposite about the biosynthesis of them. the criteria set by way of the unique Editors have been excessive, and those books have proved important to many. The quick advances in our knowl­ fringe of the mode of motion of antibiotics and different antitumor brokers has stimu­ lated extra works within the comparable sequence (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For your time it had seemed to Dr. Konrad Springer that the time could' be ripe' for bringing the topic of the biosynthesis of antibiotics up to date. This Editor agreed to survey the literature and talk about this chance together with his colleagues who're lively in examine on antibiotics. despite the looks of diverse assessment articles, either one of a hugely particular­ ized and basic nature, at the biosynthesis of antibiotics, it was once agreed usually that it might be super worthwhile so as to add a brand new quantity on biosynthesis to the sequence. the sort of paintings may still concentrate on gathering a gaggle of contributions facing these antibiotics whose biosynthesis is known in a lot better element now than it used to be within the heart 1960's. on the grounds that quantity II on biosynthesis is still on hand, this addition to the sequence has no longer handled every antibiotic whose biosynthesis used to be studied lengthy ago.

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Chemical Degradation of 14C-Labeled Lasalocid A (Scheme 1) Pyrolytic decarboxylation of lasalocid A at 220 0 C gave radioactive CO 2 (II) only in the case of [I- 14C]acetate-derived antibiotic, showing that C-I in (I) is derived from an acetate carboxyl. Retro-aldol cleavage of (I) followed by oxidation of (VI) and hydrolysis gave acetic acid (VII) from the C-methyl group at C-23 in (I). This C-methyl was shown to originate as an acetate unit by obtaining radioactive (VII) from [I- 14C]acetate-derived (I) (Table 3).

On the other hand, the elucidation of the ansamycin biosynthesis pattern has demonstrated that 13e labeling coupled with carbon magnetic resonance spectroscopy is a powerful tool that provides a relatively simple, precise method for identification of the individual carbons into which precursors are incorporated, permitting the solution of what appeared, at least in the case of rifamycin, to be a very complex puzzle. Moreover, even when the precursor of a moiety, as in the case of the aromatic ring, has not been identified, the semiquantitative determination of incorporation of the carbons of glucose by means of 13e labeling gave precise indications of the metabolic pathway by which the molecules originated.

J Antibiot Ser A 17:29-32 Thiemann JE, Zucco G, Pelizza G (1969) A proposal for the transfer of Streptomyces mediterranei Margalith and Beretta 1960 to the genus Nocardia as Nocardia mediterranea (Margalith and Beretta) Comb. Nov Arch Mikrobiol 67: 147-155 Waksman SA (1961) The actinomycetes, vol II, p 276. Williams and Wilkins Co, Baltimore Wani MC, Taylor HL, Wall ME (1973) Plant antitumor agents: Colubrinol acetate and colubrinol, antileukaemic ansa macrolide from Colubrina texensis. JCS Chem Commun 390 Weinstein MJ, Luedemann GM, Oden EM, Wagman GH (1967) Halomycin, a new Micromonosporaproduced antibiotic.

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