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By Benjamin T. Wall, Craig Porter

Curiosity in carnitine and its capability well-being merits has surged over the past decade. Carnitine serves a couple of organic roles, resembling stimulating the oxidation of fats and combating the buildup of lactic acid. it's also used as a complement for weight reduction and function enhancement. This publication discusses the capabilities carnitine fulfills in human biology, with particular emphasis on its roles in Read more...

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Annals of Clinical Biochemistry, 45(Pt 6), 585–592. , and Bagiella, E. 1989. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. European Heart Journal, 10(6), 502–508. J. 2004. Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects. Molecular Aspects of Medicine, 25(5–6), 521–532. A. 1999. Malonyl-CoA, fuel sensing, and insulin resistanc. American Journal of Physiology, 276(1 Pt 1), E1–E18. D. 1993. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.

The genetic inhibition of mitochondrial fatty acid β-oxidation through deletion of MCD (higher malonyl CoA levels) protected against diet-induced glucose intolerance despite high intramuscular levels of long-chain acyl CoAs (Koves et al. 2008). In accordance with these findings in animal models, acylcarnitines have also been implicated in insulin resistance in humans (Hoppel and Genuth 1980, Soeters et al. 2009, Mihalik et al. 2010). Several studies have reported diminished plasma carnitine levels in type 1 and 2 diabetics (Tamamogullari et al.

R. 2001. Molecular enzymology of carnitine transfer and transport. Biochimica et Biophysica Acta, 1546(1), 21–43. K. 1975. The mechanism of fatty acid uptake by heart mitochondria: an acylcarnitine-carnitine exchange. FEBS Letters, 54(1), 21–25. A. 2004. Carnitine acyltransferases and their influence on CoA pools in health and disease. Molecular Aspects of Medicine, 25(5– 6), 475–493. A. 1963. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

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