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By Stephen C. Harrison (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)

The all new suggestions in Viral Pathogenesis III comprises the commonly praised layout of featuring updated details in pithy, simply learn "mini-review" type and enhances prior versions with contributions via top overseas gurus on structure-function relationships, gene legislation, mobile biology of viral infections, transgenic mice, expression of viral genes, retroviruses, and evolving techniques in viral illnesses. Taken jointly, quantity I, II and III of Concepts in Viral Pathogenesis comprise one hundred forty five particular chapters every one representing the newest considering in vital components of virology through the main investigators within the box. Clinicians, laboratory scientists, scholars, and others looking authoritative overviews of present wisdom at the mechanism of viral ailments will welcome this necessary resource.

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Extra resources for Concepts in Viral Pathogenesis III

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This property might attenuate neurovirulence by reducing the efficiency of viral replication in the CNS. The mutation might also affect a step in virion binding, entry, or uncoating in a cell-type-specific manner that is not related to the ts phenotype. An example of such a mechanism is provided by mutations in VPl of P2/Lansing that reduce its replication and neurovirulence in the mouse CNS, but do not alter replication in cultured cells [14] (see below). The only specific base changes that have been associated with the attenuated phenotype are those around 480 of all three vaccine serotypes and the mutation in VP3 of P3/Sabin.

La Monica N, Almond JW, Racaniello VR (1987) A mouse model for poliovirus neurovirulence identifies mutations that attentuate the virus for humans. J Virol 61 :2917-2920 13. Svitkin YV, Maslova SV, Agol V (1985) The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology 147:243-252 14. La Monica N, Kupsky W, Racaniello VR (1987) Reduced mouse neurovirulence 15. 16. 17. 18. 19. 20. 21. 22. 23. of poliovirus type 2 Lansing antigenic variants selected with monoclonal antibodies.

Could this insertion be part of the destabilization of the endosomal membrane that allows the escape of (altered) virions into the cytoplasm? , by an insect vector) and cell-to-cell transfer by passage through cytoplasmic bridges (plasmodesmata). It might be significant that the T = 3 insect viruses, which presumably enter by receptor-mediated endocytosis, have a proteolytic cleavage step is their assembly pathway [19]. It is not yet known whether these viruses can expand or whether the cleaved C-terminal peptide can exist from an expanded particle.

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