Download Cytokines and Chemokines in Infectious Diseases Handbook by Malak Kotb, Thierry Calandra PDF

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By Malak Kotb, Thierry Calandra

Univ. of Tennessee, Memphis. textual content offers a finished evaluate of cytokines and chemokines in immunity and human infectious ailments. Covers bacterial, viral, fungal, and parasitic infections. contains an assessment of healing thoughts and brokers and the function in modulating host responses to pathogens and vaccines. DNLM: Chemokines--immunology.

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104, 1051–1059. 124. , et al. (1999) Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 93, 1668–1676. 125. H. (1998) Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc. Natl. Acad. Sci. USA 95, 9558–9561. 126. , et al. (1998) Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion.

1997) Congenital leptin deficiency is associated with severe early- onset obesity in humans. Nature 387, 903–908. 31. , et al. (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341, 879–884. 32. Friedman JM and Leibel RL. (1992) Tackling a weighty problem. Cell 69, 217–220. 33. M. (1997) The alphabet of weight control. Nature 385, 119–120. 34. S. (1998) Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell.

Interestingly, human studies have reported that serum leptin levels do not necessarily correlate with the severity or the presence of colitis. This is entirely consistent with the animal model, whereby at later stages of the disease, leptin levels are not particularly raised. The ob/ob mice are protected from induction of this disease and this protection is reversed by administration of exogenous recombinant leptin. Furthermore, much lower levels of the proinflammatory cytokines IFN-γ, TNF-α, and IL-18 were found in the ob/ob mice in this model.

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