By Malak Kotb, Thierry Calandra
Univ. of Tennessee, Memphis. textual content offers a finished evaluate of cytokines and chemokines in immunity and human infectious ailments. Covers bacterial, viral, fungal, and parasitic infections. contains an assessment of healing thoughts and brokers and the function in modulating host responses to pathogens and vaccines. DNLM: Chemokines--immunology.
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Interestingly, human studies have reported that serum leptin levels do not necessarily correlate with the severity or the presence of colitis. This is entirely consistent with the animal model, whereby at later stages of the disease, leptin levels are not particularly raised. The ob/ob mice are protected from induction of this disease and this protection is reversed by administration of exogenous recombinant leptin. Furthermore, much lower levels of the proinflammatory cytokines IFN-γ, TNF-α, and IL-18 were found in the ob/ob mice in this model.