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By J. Monsonego

Regardless of the sizeable efforts made to avoid the sickness by means of early detection, cervical melanoma is still a number one reason for mortality between girls around the world. the eu study association on Genital an infection and Neoplasia (EUROGIN) pursues a wide selection of academic and coaching actions, aiming to unfold actual and cutting-edge info within the box of cervical melanoma prevention. the most recent final result of those actions is gifted during this book.Providing a concise replace of the present wisdom on human papillomavirus (HPV) infections and their intimate hyperlink to cervical melanoma, the booklet makes a speciality of 5 interrelated themes: excessive- and low-risk HPV infections, tools for HPV detection and use of molecular markers, HPV checking out in fundamental screening and sufferer administration, morphological analysis and therapy, in addition to prevention of cervical melanoma by means of vaccines. Written by means of prime foreign specialists, this booklet is concentrated at a multidisciplinary readership including healthiness care execs from assorted specialties engaged within the administration of HPV-associated illnesses.

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J Infect Dis 2004;190: 468–476. Lazcano-Ponce E, Herrero R, Munoz N, Hernandez-Avila M, Salmerón J, Leyva A, Meijer C, Walboomers J: High prevalence of human papillomavirus infection in Mexican males: comparative study of penile-urethral swabs and urine samples. Sex Transm Dis 2001;28:277–280. Baldwin S, Wallace D, Papenfuss M, Abrahamsen M, Vaught L, Kornegay J, Hallum J, Redmond S, Giuliano A: Human papillomavirus infection in men attending a sexually transmitted disease clinic. J Infect Dis 2003;187:1064–1070.

Obstet Gynecol 1992;79:328–337. Bauer H, Hildesheim A, Schiffman M, Glass A, Rush B, Scott D, Cadell D, Kurman R, Manos M: Determinants of genital human papillomavirus infection in low-risk women in Portland, Oregon. Sex Transm Dis 1993;20:274–278. Nindl I, Lorincz A, Mielzynska I, Petry U, Baur S, Kirchmayr R , Michels W, Schneider A: Human papillomavirus detection in cervical intraepithelial neoplasia by the second-generation hybrid capture microplate test, comparing two different cervical specimen collection methods.

A non-intervention follow-up study of women with cytological evidence of low-grade cervical intra-epithelial neoplasia showed that HPV16 E2-specific T cell responses, as measured by specific IL-2 release in vitro, occurred frequently at the time of lesion clearance [26]. Good Th1-type immunity against the E2 and E6 protein has been detected in healthy individuals with no clinical signs of HPV16 infection [27, 28]. Importantly, these Th1-type responses were found only occasionally in high-grade cervical intra-epithelial neoplasia patients and were impaired in cervical cancer patients [29].

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