By Pedro R. Lowenstein, Maria G. Castro
Coedited by way of across the world famous leaders in gene treatment learn, this consultant provides the newest advances, experiences, and professional opinion on gene treatment for neurological problems. Spanning stipulations equivalent to Parkinsons's and Alzheimer's ailment, a number of sclerosis, mind tumors, stroke, epilepsy, and mind and spinal wire trauma, this reference provides the elemental technological know-how and purposes of recombinant gene items, immune and stem cell-mediated healing concepts, and mind tumor gene remedy.
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Additional resources for Gene Therapy for Neurological Disorders
Adaptive immune response. The adaptive immune response is further divided into cellmediated or humoral responses. Cell-Mediated Immune Response Cellular effector T cells provide a specific, long-term, memory response to the antigen, compared to the response acheived by the innate immune system. Activated T lymphocytes recognize foreign antigenic epitopes displayed by MHC molecules on the surface of infected cells. T cells, through specific interactions with their antigens, can either secrete cytokines, such as IFN-g, or TNFa, or kill target cells through mechanisms that utilize the proteins perforin, and/or Fas-Ligand.
15. Paludan SR, Ellermann-Eriksen S, Kruys V, Mogensen SC. Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the 3’ untranslated region. J Immunol 2001; 167:2202–2208. 16. Sato M, Suemori H, Hata N, et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
Submitted, 2005] have demonstrated that the systemic immune response is dependent on both sets of CD4C and CD8C T cells, IFNg and perforin, and leads to the phagocytosis and cell death of at least a significant number of transduced cells. Even though our data strongly suggest the existence of cell death during the adaptive immune response mediated elimination of transgene expression from the brain, the exact percentage of elimination that proceeds by cell death versus that resulting from functional inhibition of transgene expression from the vectors, remains to be fully explored (Fig.