By Robin K Ohls MD, Akhil Maheshwari MD
This fascinating new reference brings you information regarding the main debatable hematology, immunology, and infectious ailment demanding situations you face on your perform. The ebook optimistically tackles those topics and provides professional suggestion at the newest diagnostic and therapy suggestions utilizing evidence-based drugs anyplace attainable. It can provide the newest info you must preserve speed with the fast paced, dynamic setting of neonatology.Addresses arguable themes head on, so that you can make a decision the way to deal with those tricky perform issues.Serves because the bridge among the newest state of the art study and its software to scientific perform. Assembles a world-class staff of neonatologists, representing the genuine leaders of the strong point, to make sure the main authoritative content material to be had.
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Extra resources for Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies
Biol Neonate 70:322–327, 1996. 68. Pietrucha T, Wojciechowski T, Greger J, et al. Differentiated reactivity of whole blood neonatal platelets to various agonists. Platelets 12:99–107, 2001. 69. Kuhne T, Imbach P. Neonatal platelet physiology and pathophysiology. Eur J Pediatr 157:87–94, 1998. 70. Grosshaupt B, Muntean W, Sedlmayr P. Hyporeactivity of neonatal platelets is not caused by preactivation during birth. Eur J Pediatr 156:944–948, 1997. 71. Rajasekhar D, Kestin AS, Bednarek FJ, et al. Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood.
There still remains hope that certain types of patients may respond to one or a combination of these factors, and thus their modes of action and potential use in the NICU will be briefly discussed. Clinical studies using IL-3 and IL-6 alone or in combination for adult bone marrow failure, HIV-associated cytopenias, and congenital amegakaryocytic 24 2 thrombocytopenia have demonstrated limited efficacy and/or significant toxicity, thus making their therapeutic use impractical (147–160). Recombinant IL-11 is the only thrombopoietic growth factor that has been approved by the FDA for the prevention of severe thrombocytopenia after myelosuppressive chemotherapy for nonmyeloid malignancies (161), although significant side-effects such as fluid retention and atrial arrhythmias may limit its use (162, 163).
111. Saxonhouse MA, Rimsza LM, Stevens G, et al. Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonates. Biol Neonate 89:104–108, 2005. 112. Saxonhouse MA, Rimsza LM, Christensen RD, et al. Effects of anoxia on megakaryocyte progenitors derived from cord blood CD34pos cells. Eur J Haematol 71:359–365, 2003. 113. Harker LA, Finch CA. Thrombokinetics in man. J Clin Invest 48:963–974, 1969. 114. Cole JL, Marzec UM, Gunthel CJ, et al. Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients.