By Antonio Rodriguez-Moreno, Talvinder S. Sihra
This quantity seriously examines the practical activities of the kainate‑type glutamate receptors (KARs). Following on from the bigger physique of labor at the NMDA‑ and AMPA-type ionotropic glutamate receptors (GluRs), reports with KARs have constantly thrown up exceptions to common ideas approximately synaptic modulation. individuals herein supply an perception to the idiosyncracies that now nearly typify the KAR box. The attention-grabbing insights supplied during this quantity serve to inspire looking out mechanistic questions.
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Additional info for Kainate Receptors: Novel Signaling Insights
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49 In a study aimed at elucidating the motility of axonal filopodia and dendritic spines during postnatal development, a process thought to be involved in synapse formation and rearrangement, it was demonstrated that synaptic activation of KARs enhances motility at mossy fiber axons in younger hippocampal slice culture but inhibits it in more mature slices,50 suggesting a key role for KARs for establishing synaptic contacts and for stabilizing newly formed ones. More extensive studies relate to the functional role that KARs exert on network activity in the immature hippocampus.
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