By Farber J.M.
MIG (monokine precipitated via I FN7) is a non-ELR CXC chemokine ligand for CXCR3. a receptor expressed totally on T cells and NK cells. not like comparable chemokines, MIG encompasses a lengthy C-terminal extension that's topic to inactivating proteolytic processing. MIG is triggered in quite a number cells together with macrophages, endothelial cells, and parenchymal cells, basically based on IFN7. MIG is a che mo tactic issue for T cells, rather following T mobile activation, and has been proven to urge adhesion of activated T cells to endothelial cells. MIG's basic position in vivo is presumed to be within the recruitment of T cells and NK cells to inflammatory websites the place IFN7 is being made. MIG has additionally been came across to inhibit colony formation from hematopoietic progenitors in vitro and to inhibit tumor development and angiogenesis in vivo.
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G. T T T for phenylalanine occurs only four times in more than 12 kb of accumulated Streptomyces coding sequence, compared with 176 occurrences of its synonym T T C ; M. J . Bibb, personal communication). We may therefore postulate that the Streptomyces enzyme does not need, or have, a stabilizing function for rU-dA pairs. There is even less information for nonenteric bacteria about factor-dependent terminators and the role of RNA polymerase-associated termination factors such as rho and the nusA gene product that have been analysed in E.
Johnston, A. W. B. and Kondorosi, A. (1984). Genetic maps of Rhizobium leguminosarum, R. meliloti, R. phaseoli and R. trifolii. In "Genetic Maps 1984" (S. J. ), pp. 202-205. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. (5) Vary, P. A. and Tao, Y-P. (1988). Development of genetic methods in Bacillus megaterium.
Attenuation C. Regulation by Anti-Termination D. Genetic Regulation by Complementary RNA Species ("Antisense RNA") E. Regulation of Gene Expression by Changes in DNA Structure VI. Differences between Prokaryote and Eukaryote Genetics A. Chromosome Structure B. Plasmids C. Merodiploidy D. Gene Expression E. Opérons and Introns VII. Closing Remarks Acknowledgements References 23 24 24 24 24 25 26 30 30 31 32 32 33 33 36 36 38 38 39 40 40 41 43 43 43 44 44 45 45 46 46 24 K. F. Chater and D. A. Hopwood I.