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14, 10531-10549 Kohn, K. W. and Spears, C. L. (1967). Alkylated DNA: buoyant density changes and mode of decomposition. Biochim. Biophys. , Newman, R. A. and Lown, J. W. (1988). Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. J. Med. , Pullman, A. and Pullman, B. (1981). Steric accessibility of reactive centers in B-DNA. Int. J. , Rhodes, A. , Forrow, S. and Hartley, J. A. (1993a). In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin.

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