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By James F Collins

Molecular, Genetic, and dietary features of significant and hint Minerals is a distinct reference that gives an entire assessment of the non-vitamin micronutrients, together with calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.

In addition, the ebook covers the dietary and toxicological houses of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, in addition to ultra-trace minerals and people without confirmed nutritional requirement for people. clients will locate in-depth chapters on every one crucial mineral and mineral metabolism, in addition to discussions of nutritional thoughts within the usa and round the world.

  • Presents the single medical connection with hide all the nutritionally suitable crucial significant and hint minerals
  • Provides a large introductory bankruptcy on every one mineral to offer readers priceless historical past and context
  • Clarifies the mobile and molecular facets of every mineral and its genetic and genomic aspects
  • Includes insurance of all nutritionally correct minerals―essential significant hint minerals and ultra-trace minerals
  • Underscores the real interactions among minerals so readers learn the way metabolism of 1 mineral affects another

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Example text

In the presence of physiological concentrations of extracellular Ca2+, activation of the CaSR via l-type amino acids leads to gastric acid secretion. , 2001). This is exemplified nicely in the CaSR knockout mice. Gastrin release was negligible after administration of Ca2+ by oral gavage in the CaSR knockout mice. , 2010). The insensitivity of the G cell, in the absence of CaSR, to pH and luminal contents further supports the role of CaSR in gastric acid secretion (Geibel and Hebert, 2009). , 2001).

Secretion increases due to downregulation of the CaSR. PTH produces two actions: (1) enhanced bone resorption to increase the availability of Ca2+ in serum and (2) increased renal production of 1,25-dihydroxyvitamin D3, which stimulates Ca2+ absorption in the GI tract. Concurrently, the CaSR located in the thyroid gland prevents calcitonin secretion. , 2011). When extracellular Ca2+ increases, CaSR expression increases, which decreases PTH released into the circulation by acting at multiple levels (Brown, 2007a).

Gastrointest. Liver Physiol. 297 (4), G781–G791. 2008. , 2014. Calcium-sensing receptor 20 years later. Am. J. Physiol. Cell Physiol. 307 (3), C221–C231. 2014. , 2014. Vitamin d receptor, a tumor suppressor in skin. Can. J. Physiol. Pharmacol. 1–6. 1139/cjpp-2014-0367. , 2004. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N. Engl. J. Med. 350 (15), 1516–1525. 1056/NEJMoa031633. , 1993. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.

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