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By R. C. Brand, W. Hennig (auth.), J. R. Harris, I. B. Zbarsky (eds.)

This choice of one zero one brief communications, submitted by means of a number of the members on the eleventh Nuclear Workshop held in Suzdal, USSR, 18-23 September, 1989, presents a consultant survey of the fabric awarded on the Workshop. Articles were submitted through either those that added lectures and people who had poster shows. The order of presentation on the Nuclear Workshop is approximately maintained inside of this complaints publication, however the consultation titles in the clinical software haven't been applied as discrete subdivisions in the e-book, due to the massive overlap of subject material. the final series is as follows: Genome constitution, Gene constitution and Expression, Nucleolar Genes, constitution and Proteins, Chromatin and Nuclear Granules, Nuclear Matrix and Nuclear Proteins, Replication and Transcription and at last Nuclear Envelope and Nuclear Cytoplasmic delivery. a number of articles on Nuclear Lipids also are incorporated, stemming from a night round-table dialogue on lipids. The 3rd Wilhelm Bernhard Lecture was once added in Suzdal through Professor Harris Busch, who should be obvious within the photo above (on the left) within the presence of Professor Ilya B. Zbarsky, President of the organizing committee for the eleventh Nuclear Workshop. (Previous Wilhelm Bernhard academics were Ronald H. Reeder, in Krakow, Poland, 1985 and Oscar L. Miller, Jr. , in Stevensbeek, The Netherlands, in 1987).

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Abc Figure I. i 60 conformational state of DNA and may become involved in the regulation of gene activity. The results of the analysis of the derived amino acid sequences of a- and S-parts of both fragments demonstrated that at the N-ends there were 16 amino acids with the properties of a signal peptide (Heijne, 1984). Potential glycosylation and phosphorylation sites were identified. Posttranslation modifications of this kind are the feature of the secretion glycoproteins encoded by the BRs (Hamodrakas, Kaftos, 1984).

_ 6s_ _ I 2 • ,1 C , ••••••• V /2 ~ _ _ _L1-1 ' Figure I. Clusters of Alu-family DNA repeats in chromosome 6 of PHAstimulated lymphocytes of one normal donor. Tritiumlabeled DNA of genomic lambda clone CAR42, containing multiple Alu repeats is used as a probe. , 1987). 2, 7q22 and 7q32-q34, all of which are R-positive. With the trltlum method we have also detected Alu clusters in some leukaemia patients over 7q22 (Table I) and 7q32-q34. However, in U937 cells we never detected an increased fluorescence over 7pter and 7qter, in agreement with the data (Table I) obtained with a tritiated Alu-DNA.

Taxons are classified as in th~ original data bank (5). Figure 1. 28 Structural levels of DNA packaging in chromatin of eukaryotes. (A) Unravelled chromomere loop with the preserved nucleosomal structure (about 400 nucleosomes on the 20 ~ m long loop). (B,C) The loops of variable size (black arrows) compose the rosette-like structure through interacting granulae at their bases (white arrows). (D) Nucleosomes are not evenly distributed along the DNA molecule. (A,D) polytene chromosomes of Chironomus thurnrni; (B,C) rat liver chromatin.

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