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By Edward J. Atkins, Valérie Biousse, Nancy J. Newman (auth.), Birgit Lorenz, Francois-Xavier Borruat (eds.)

Te sequence necessities in Ophthalmology used to be initi- to debate clinically suitable and acceptable to- ated years in the past to expedite the well timed trans - ics. Summaries of clinically proper details fer of recent details in imaginative and prescient technological know-how and feature been supplied all through each one bankruptcy. evidence-based drugs into scientific perform. every one subspecialty sector now has been lined We suggestion that this prospicient concept will be as soon as, and the reaction to the frst 8 volumes moved and guided by way of a resolute dedication within the sequence has been enthusiastically confident. to excellence. it truly is moderate to now replace our With the beginning of the second one cycle of subspecialty readers with what has been accomplished. insurance, the dissemination of sensible informa - Te instant aim was once to move informa - tion can be persevered as we research extra approximately tion via a top quality quarterly booklet the rising advances in a variety of ophthalmic during which ophthalmology will be represented through subspecialties that may be utilized to procure the 8 subspecialties. during this regard, every one factor has very best care of our sufferers. in addition, we had a subspecialty subject matter and has been overseen will proceed to focus on clinically suitable i- through the world over well-known quantity edi - formation and retain our dedication to e- tors, who in flip have invited a bevy of specialists cellence. G. okay. Krieglstein R. N.

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18. 19. 20. 21. 22. References Beck RW, Chandler DL, Cole SR et al (2002) Interferon β-1a for early multiple sclerosis: CHAMPS trial subgroup analyses. Ann Neurol 51:481–490 Bermel R, Puli S, Rudick R et al (2005) Gray mater MRI T2 hypointensity predicts longitudinal atrophy in multiple sclerosis. Arch Neurol 62:1371–1376 Boomer JA, Siatkowski RM (2003) Optic neuritis in adults and children. Semin Ophthalmol 18:174–180 Brady KM, Brar AS, Lee AG et al (1999) Optic neuritis in children: clinical features and visual outcome.

The 24-month follow-up data from the study confirmed the initial 6 months report. This technique is not currently recommended for the treatment of NAION. Transvitreal radial optic neurotomy has been proposed as a therapy for both central retinal vein occlusion (CRVO) and NAION [58]. The procedure involves a pars plana vitrectomy and induced posterior vitreous detachment, associated with a stab incision at the nasal margin of the optic disc, with the purpose of opening the scleral canal and relieving compression of an edematous optic nerve.

It has been emphasized that, once axonal damage occurs, it may result in permanent neurological deficits. The issue of axonal damage and gray matter atrophy is at the center of the ongoing debate over whether to intervene early with immunomodulatory agents in patients with clinically isolated syndromes [4, 27], especially those predicted to be at high risk for the subsequent development of MS. Results of the CHAMPS [16] ETOMS [18], and BENEFIT [26, 56] studies suggest that patients with optic neuritis and abnormal baseline MRI (“high-risk patients”) should be considered for interferon beta therapy.

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