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8. , Annals of the New York Academy of Sciences 231(1974)108. , 30(1968)7350 10. , 34(1972)65. , Nelson, W. E o , Halberg, F. , Tokyo, 1974. G VASSILEVA-POPOVA. A. ALEXANDROV. AND M. , New York 1968. B. , London 1963. 14. S. in: Quantum Mechanics, Nauka, Moscow 1973 (in Russian) 0 15. Gynec. 107 (1970)IIII. 16. , Rathnam, P. , Endocr. Experimentalis 7(1973)19. 17. Haour, F. , 249(1974) 2195. 18. L. , Endocrinology 91(1972)463. 19. Gospodarowicz, D. (in press, 1974)0 20. Vo, Sel'kov, EoE. , Studia biophysica, 41(1973)193.

And 65-76 (1968). 121, 9. J. Lang & Muller, Computer Phys. Commun. (1971). ~, (1968)0 53-63 79-86 "System Identification", J. Wiley & Sons, 1974. 10. P. Eykhoff, New York, 11. J. R. J. Williams, "Feedback and Control Systems", Schaum Publishing Company, New York, 1967. 12. M. Paton, Proc. Roy. Soc. London (1961). B. K. L. Chakarov Institute of Oncology, Bulgarian Academy of Sciences, Sofia, Bulgaria The changes observed in complex control systems (CS) is due to regulating factors (RF) exceeding the action of the random outside effects.

Block 3 was assumed to be the receptor compartment; block 1 was assumed to be an additional diffusion barrier between bath an receptor compartment,whereas 30 O. WANNER AND V. PLISKA block 4 seemed to account for the nonideal form of the experimental input signal. So far, it has not been possible to find any real equivalent for block 2. This additional element, first detected by the identification, is responsible for the so-called "fade phenomenon" /2/ and is very important for a good fit because its time constant T2 is greater than all others except T3 , and its absence is the main reason for the failure of the model based only on ~ priori knowledge.

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