By Minoru Kanehisa
The genome initiatives have now entered a fast construction part with whole genome sequences and entire gene catalogues already on hand for a few organisms and an expanding quantity anticipated presently. furthermore the recent DNA and protein chip applied sciences can produce sensible info approximately genes comparable to gene expression profiles at a fast cost. there's accordingly a wide and ever expanding quantity of knowledge approximately genes and molecules. although there's nonetheless an immense hole among info on the molecular point and data on the point of built-in organic structures. it really is this hole that's addressed in Post-genome Informatics. Post-genome informatics is the research of organic capabilities when it comes to the community of interacting molecules and genes with the purpose of realizing how a organic procedure is prepared from its person construction blocks. in addition to containing a entire survey of the database and computational applied sciences suitable to molecular series research, Post-genome Informatics will give you the reader with a conceptual framework and sensible tools for the illustration and computation of molecular networks.
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Additional info for Post-genome Informatics
Central intermediary metabolism C. Respiration (aerobic and anaerobic) D. Fermentation E. ATP-proton motive force interconversion F. Broad regulatory functions II. Biosynthesis of small molecules A. Amino acids B. Nucleotides C. Sugars and sugar nucleorides D. Cofactors, prosthetic groups, electron carriers E. Fatty acids and lipids F. Polyamines III. Macromolecule metabolism A. Synthesis and modification B. Degradation of macromolecules IV Cell structure A. Membrane components B. Murein sacculus C.
An essence of life is the dynamics of the information flow, both vertical (information transmission) and horizontal (information expression), which is an ordered sequence and collection of chemical reactions. In fact, the reactions of the biological macromolecules that underlie, for example, transcription 22 Blueprint of life Perturbation — Dynamic Response Environmental change Gene disruption Gene overexpression Changes in: Gene expression profiles, etc. Basic Principles Practical Applications Biological Knowledge Molecular and Cellular Biology, Biochemistry, Genetics, etc.
In the object-oriented programming, objects are independent program modules that serve as the building blocks of many applications. In the object-oriented database the data are stored as objects and managed by an object-oriented database management system. Because of the abstract data type the object-oriented database has far greater flexibility for data representation than the relational database or the deductive database. However, it has less computational capacity because it lacks any mathematical or logical foundation such as relational Informatics technologies 41 algebra or predicate logic.