By Ricardo Insausti
The postnatal improvement of the human hippocampal formation (HF) is topic of accelerating curiosity as a result of its implication in very important pathologies that abate the conventional improvement of kids. during this paintings, the authors current a glimpse of the most occasions that represent vital milestones within the improvement and shaping of a few of crucial mental features corresponding to autobiographical reminiscence. even if they tested a few circumstances within the final trimester of gestation, their description starts off at delivery, round forty gestational weeks. Serial sections with thionin for Nissl research printed that each one fields of the HF have been current and identifiable at beginning. besides the fact that, the relative development of the cortical mantle used to be a lot greater relative to the HF. the most structural alterations happened through the first postnatal yr, particularly within the dentate gyrus and within the entorhinal cortex. At next a while, a progress in measurement was once famous in all elements of the HF. This development was once extra glaring on the physique and tail of the hippocampus, as evidenced by means of measurements of the neuroanatomical sequence. furthermore, the authors tested every so often the MRI visual appeal of the HF at assorted postnatal a while bought by way of autopsy imaging. MRI neuroanatomical sequence supplied anatomically pointed out landmarks necessary for the MRI identity of alternative parts of the HF in the course of postnatal development.
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Additional info for Postnatal Development of the Human Hippocampal Formation
The rostral pole of the DG appears at the uncal portion of the hippocampus as a circular structure that corresponds to the rostralmost extreme of the DG, tangentially cut so that it acquires a closed culde-sac appearance (Fig. 1a). The medial bend of the DG ends at the band of Giacomini (asterisk in Fig. 4b) near the gyrus intralimbicus, immediately caudal to the band of Giacomini. The most common appearance of the DG as a U-shaped structure is visible in the body of the hippocampus (Fig. 1c). The DG increases in complexity towards its caudal end, mostly due to the tilt of the hippocampal tail and thus the obliquity of the plane of section.
In this proposal, the HF contains the so-called archicortex (also termed the allocortex), which presents a single cellular layer; the elements of the HF mentioned so far (DG, CA3, CA2, ◂ Fig. 7 (continued) the underlying pyramidal layer. The transition between CA1 and the subiculum forms an oblique border that is hardly seen at birth (a) but becomes progressively more apparent at one year old (b), five years old (c), and 14 years old (d). The deepest layer of the subiculum, the polymorphic layer, is inconspicuous at this magnification.
2007). In contrast, unbiased estimates of the DG volume with the Cavalieri method show that the volume of the DG in the monkey increases slightly between three weeks and three months postnatally, but the volume more than doubles between three months and 7–13 years (Lavenex et al. 2007). A clear example can be observed, for instance, in the subgranular portion of the DG, which is better defined in subsequent postnatal ages than in the newborn. While in the newborn the subgranular space contains many neurons (Figs.