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If hybrid cells are grown under non-selective conditions after the initial selection, chromosomes from one of the parents tend to be lost more or less at random. In the case of human–rodent fusions, which are the most common, the human chromosomes are preferentially lost. Eventually only one or a few chromosomes from one parent remain. In this way rodent cell lines containing one or two human chromosomes have been constructed and these can be used to isolate the individual human chromosomes by FACS.

2001) Telomeric chromatin: replicating and wrapping up chromosome ends. Current Opinion in Genetics and Development 11, 189–198. This review presents a biological perspective on telomeres and focuses on the replication of telo- ·· 33 meres, the protection of chromosome ends from DNA damage, and the establishment and maintenance of telomeric heterochromatin. Wood V. et al. (2002) The genome sequence of Schizosaccharomyces pombe. Nature 415, 871–80. This key paper was published after this edition went to press but is important because it details the differences in genome organization between S.

With bacterial colonies containing cosmids it is also possible to store an amplified library (Hanahan & Meselson 1980), but bacterial populations cannot be stored as readily as phage populations. There is often an unacceptable loss of viability when the bacteria are stored. A word of caution is necessary when considering the use of any amplified library. There is the possibility of distortion. g. variations in target DNA size or sequence may affect replication of a recombinant phage, plasmid or cosmid.

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