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By Rossen Donev

Structural genomics is the systematic decision of three-d buildings of proteins consultant of the diversity of protein constitution and serve as present in nature. The aim is to construct a physique of structural details that might are expecting the constitution and capability functionality for nearly any protein from wisdom of its coding series. this is often crucial info for knowing the functioning of the human proteome, the ensemble of tens of hundreds of thousands of proteins laid out in the human genome.While so much structural biologists pursue buildings of person proteins or protein teams, experts in structural genomics pursue constructions of proteins on a genome broad scale. this suggests huge scale cloning, expression and purification. One major benefit of this technique is economic system of scale. Key Features*Examines the 3 dimensional constitution of all proteins of a given organism, via experimental tools equivalent to X-ray crystallography and NMR spectroscopy * appears at structural genomics as a origin of drug discovery as gaining knowledge of new drugs is turning into more difficult and the pharmaceutical is asking to new applied sciences to assist during this project

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Phys. Lett. 407, 205–208. , Vracko, M. (2008). On novel representation of proteins based on amino acid adjacency matrix. SAR QSAR Environ. Res. 19, 339–349. , Plavsic, D. (2003a). Analysis of similarity/dissimilarity of DNA sequences based on novel 2-D graphical representation. Chem. Phys. Lett. 371, 202. , Plavsic, D. (2003b). Novel 2-D graphical representation of DNA sequences and their numerical characterization. Chem. Phys. Lett. 368, 1. , Basak, S. C. (2000). On 3-D graphical representation of DNA primary sequences and their numerical characterization.

24. Eddy, S. R. (1996). Hidden Markov models. Curr. Opin. Struct. Biol. 6, 361–365. Engelman, D. , Steitz, T. , Goldman, A. (1986). Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu. Rev. Biophys. Biophys. Chem. 15, 321–353. Estrada, E. (2002). Characterization of the folding degree of proteins. Bioinformatics 18, 697–704. , Uriarte, E. (2001). Recent advances on the role of topological indices in drug discovery research. Curr. Med. Chem. 8, 1573–1588.

13, 165–183. Perutz, M. , Rossmann, M. , Cullis, A. , North, A. C. (1960). 5-A. resolution, obtained by X-ray analysis. Nature 185, 416–422. Perutz, M. , Weisz, O. (1947). Crystal structure of human carboxyhaemoglobin. Nature 160, 786. , Bui, H. , et al. (2005). The design and implementation of the immune epitope database and analysis resource. Immunogenetics 57, 326–336. 40 GHOSH AND NANDY Phillips, R. , Nixon, D. , Gotch, F. , Edwards, J. , Ogunlesi, A. , et al. (1991). Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.

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