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By Kenneth S., M.D. Kendler, Lindon, Ph.D. Eaves

Книга Psychiatric Genetics Psychiatric GeneticsКниги Медицина Автор: Kenneth S., M.D. Kendler, Lindon, Ph.D. Eaves Год издания: 2005 Формат: pdf Издат.:American Psychiatric Publishing Страниц: 256 Размер: 1,7 ISBN: 1585622281 Язык: Английский0 (голосов: zero) Оценка:Psychiatric Genetics is a concise reference that provides the complexities of this dynamic box in a truly written, simply available structure, with a variety of tables and illustrations. Ten professional participants supply a desirable view of psychiatric genetics in a textual content that's thorough and scholarly but additionally succinct and available. The creation summarizes the field's 4 unique paradigms and their interrelationships that aid us comprehend the function of genetic elements within the etiology of psychiatric problems: uncomplicated genetic epidemiology, which demonstrates heritability; complex genetic epidemiology, which explores the character and mode of motion of those genetic danger components; gene discovering, which permits us to deduce the likelihood locus within the genomic quarter lower than research contributes to psychiatric affliction legal responsibility; and molecular genetics, which strains the organic mechanisms through which the DNA version pointed out utilizing gene discovering tools contributes to the illness itself.

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Does the effect of genetic variants on offspring depend on which parent they were inherited from (imprinting)? Do genetic differences in mothers, for example, affect the environment of offspring (maternal effects)? Do some genetic effects influence multiple outcomes (comorbidity, genetic covariance, pleiotropy)? For example, is the correlation between anxiety and depression the result of a common underlying genetic liability? To what extent do genetic effects on antisocial behavior contribute to genetic risk to substance use and abuse?

Are “shared” environmental effects created by parents? )? 4. Do environmental influences have a lasting effect on psychiatric outcomes, or are their effects relatively transient? That is, are people permanently traumatized by experience, or do they recover from adversity? 5. What are the specific environmental influences on particular outcomes? To what extent do these result from social learning, and to what extent do they result from physical experience (accident, infection, pre- and perinatal events)?

Treating genes and environment in isolation from each other may lead us to miss essential characteristics of human behavior and its disorders. Humans have a remarkable facility to create and evaluate their environment—a process that primarily involves providing extended parental care and living together in families and other complex social groups. Human development is a conversation between genes and their environment that modifies the expression of genes and shapes the environment in 28 PSYCHIATRIC GENETICS which development occurs.

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