Download Receptor Tyrosine Kinases: Structure, Functions and Role in by Deric L. Wheeler, Yosef Yarden PDF

Posted by

By Deric L. Wheeler, Yosef Yarden

Receptor Tyrosine Kinase: constitution, features and function in Human Disease, for the 1st time, systematically covers the shared structural and useful good points of the RTK relations. Receptor Tyrosine Kinases (RTKs) play severe roles in embryogenesis, basic body structure and several other ailments. And during the last decade they've got turn into the Number 1 goals of melanoma medicinal drugs. with the intention to behavior primary learn or to try to boost pharmacological brokers capable of improve or intercept them, it really is crucial first to appreciate the evolutionary beginning of the fifty eight RTKs and their roles in invertebrates and in people, in addition to downstream signaling pathways. The meeting of chapters is written via specialists and underscores commonalities among and one of the RTKs. it truly is an amazing significant other quantity to The Receptor Tyrosine Kinase: households and Subfamilies, which proceeds, relations by way of relations via all the particular subfamilies of RTKs, in addition to their precise landmarks.

Show description

Read Online or Download Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease PDF

Best molecular biology books

Advanced molecular biology: a concise reference

This publication emphasises the unifying rules and mechanisms of molecular biology, with widespread use of tables and packing containers to summarise experimental information and gene and protein features.

CRYO-EM, PART B: 3-D RECONSTRUCTION

This quantity is devoted to an outline of the tools, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the tips, intrumentation, and techniques underlying all cryo-EM techniques which permit practictioners to simply movement among them. inside every one part, the articles are ordered based on the commonest symmetry of the pattern to which their tools are utilized.

DNA Structures Part A: Synthesis and Physical Analysis of DNA

To appreciate the buildings and dynamics of DNA and its interactions with ligands, a whole research of its confirmational flexibility is needed. This quantity and its significant other, quantity 212 of equipment in Enzymology, collate in a single resource the entire equipment and methods had to do so target

Applications of Chimeric Genes and Hybrid Proteins Part A: Gene Expression and Protein Purification

The seriously acclaimed laboratory regular for greater than 40 years, equipment in Enzymology is likely one of the such a lot hugely revered courses within the box of biochemistry. due to the fact 1955, each one quantity has been eagerly awaited, often consulted, and praised by way of researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence includes a lot fabric nonetheless appropriate today--truly a necessary ebook for researchers in all fields of lifestyles sciences

Extra resources for Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Sample text

Biochemistry. 2012;51:1464–75. 47. Brognard J, Zhang YW, Puto LA, Hunter T. Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase. Cancer Res. 2011;71:3152–61. 48. Initiative TAG. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature. 2000;408:796–815. 49. Bemm F, Schwarz R, Forster F, Schultz J. A kinome of 2600 in the ciliate Paramecium tetraurelia. FEBS Lett. 2009;583:3589–92. 50. Liu BA, Nash PD. Evolution of SH2 domains and phosphotyrosine signalling networks.

Srivastava M, Simakov O, Chapman J, Fahey B, Gauthier ME, Mitros T, et al. The Amphimedon queenslandica genome and the evolution of animal complexity. Nature. 2010;466:720–6. 23. Manning G, Reiner D, Lauwaet T, Dacre M, Smith A, Zhai Y, et al. The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology. Genome Biol. 2011;12:R66. 24. Forrest AR, Taylor DF, Crowe ML, Chalk AM, Waddell NJ, Kolle G, et al. Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.

Unpublished. 56. Nichols SA, Roberts BW, Richter DJ, Fairclough SR, King N. Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/beta-catenin complex. Proc Natl Acad Sci U S A. 2012;109:13046–51. 57. Lim WA, Pawson T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010;142:661–7. 58. Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, et al. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.

Download PDF sample

Rated 4.08 of 5 – based on 12 votes