By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Review of the Department of Energy's Genomics: GTL Program
The U.S. division of strength (DOE) promotes clinical and technological innovation to develop the nationwide, financial, and effort safety of the USA. spotting the opportunity of microorganisms to provide new power possible choices and remediate environmental infection, DOE initiated the Genomes to existence application, now referred to as Genomics: GTL, in 2000. this system goals to increase a predictive figuring out of microbial structures that may be used to engineer structures for bioenergy construction and environmental remediation, and to appreciate carbon biking and sequestration. This file presents an overview of this system and its infrastructure plan. total, the document unearths that GTLâ€™s study has led to and supplies to bring many extra medical developments that give a contribution to the success of DOEâ€™s ambitions. notwithstanding, the DOEâ€™s present plan for construction 4 self reliant amenities for protein creation, molecular imaging, proteome research, and platforms biology sequentially will not be the main economical, effective, and scientifically optimum option to supply this infrastructure. in its place, the document indicates developing as much as 4 institute-like amenities, every one of which integrates the functions of all 4 of the initially deliberate facility varieties and makes a speciality of one or of DOEâ€™s challenge ambitions. the choice infrastructure plan can have a particularly excessive ratio of medical gain to price as the want for know-how may be without delay tied to the biology objectives of the program.
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Extra info for Review of the Department of Energy's Genomics, GTL program
The Genomics: GTL program can play an important role in increasing understanding of the structure and functions of genes associated with degradation of polysaccharides by those microorganisms. It can also contribute to the discovery of new polysaccharide-degrading enzymes by prospecting for novel 28 REVIEW OF THE DEPARTMENT OF ENERGY’S GENOMICS: GTL PROGRAM microorganisms in exotic environments. For example, termites degrade polysaccharides. Bacteria that live in a termite’s hindgut break down plant matter and release hydrogen as a byproduct.
To develop biological solutions for remediation of soil, sediment, and groundwater contaminated with metals, radionuclides, and organic hazardous wastes. • To understand relationships between climate change and Earth’s microbial systems and to generate options for carbon sequestration. The Genomics: GTL program is expected to provide the scientific underpinning for predicting and manipulating the behavior of complex biological systems, particularly systems that may play a central role in developing biotechnology solutions to fulfill DOE’s energy and environmental mandates.
Beyond simulations, there is little available mathematical theory that could be applied to the transient behavior of such systems. Thus, there is a tremendous opportunity for the Genomics: GTL program to lead the effort to bring systems mathematics to the challenges of bioremediation. Merging metabolic and field-scale models is a daunting task that requires a strong multidisciplinary approach. The Genomics: GTL program can address several essential elements, including the following problems: • Identify and characterize the multiprotein complexes—“protein machines”—that perform most cell functions in microorganisms.