Download The Development of the Sarcoplasmic Reticulum by Anthony Martonosi PDF

Posted by

By Anthony Martonosi

Sarcoplasmic reticulum is a sort of endoplasmic reticulum present in huge amounts in mature muscle cells. Anthony Martonosi provides basic information regarding the improvement and serve as of the sarcoplasmic reticulum inside a framework of up to date examine at the molecular biology of biosynthetic and signaling strategies. concentrating on the improvement of the sarcoplasmic reticulum, Martonosi demonstrates the regulatory capabilities that keep an eye on the construction of its molecular elements and investigates the interplay of those lipid and protein molecules with the myogenic, neurogenic and hormonal stimuli found in constructing muscle cells. Martonosi presents wide experimental help through the booklet.

Show description

Read Online or Download The Development of the Sarcoplasmic Reticulum PDF

Similar molecular biology books

Advanced molecular biology: a concise reference

This e-book emphasises the unifying rules and mechanisms of molecular biology, with widespread use of tables and containers to summarise experimental info and gene and protein capabilities.

CRYO-EM, PART B: 3-D RECONSTRUCTION

This quantity is devoted to an outline of the tools, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the information, intrumentation, and strategies underlying all cryo-EM methods which enable practictioners to simply movement among them. inside of every one part, the articles are ordered in response to the most typical symmetry of the pattern to which their equipment are utilized.

DNA Structures Part A: Synthesis and Physical Analysis of DNA

To appreciate the constructions and dynamics of DNA and its interactions with ligands, an entire research of its confirmational flexibility is needed. This quantity and its better half, quantity 212 of tools in Enzymology, collate in a single resource the entire tools and methods had to accomplish that target

Applications of Chimeric Genes and Hybrid Proteins Part A: Gene Expression and Protein Purification

The severely acclaimed laboratory ordinary for greater than 40 years, tools in Enzymology is without doubt one of the such a lot hugely revered courses within the box of biochemistry. considering 1955, each one quantity has been eagerly awaited, often consulted, and praised by means of researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence comprises a lot fabric nonetheless correct today--truly a necessary book for researchers in all fields of lifestyles sciences

Extra resources for The Development of the Sarcoplasmic Reticulum

Sample text

According to this model, either MyoD or Myf5 become expressed as a consequence of myogenic lineage determination. MyoD and Myf5 autoactivate their expression, but they may negatively regulate one another. Myoblast-specific genes would be regulated in proliferating myoblasts by MyoD or Myf5. Upon depletion of exogenous growth factors, MyoD or Myf5 would activate (directly or indirectly) expression of myogenin, which activates myotube-specific genes. During myofiber maturation, myogenin expression declines and MRF4 is up-regulated to control myofiber-specifk genes.

These observations suggest that MLP may be a cofactor of MDF5 and MEF2 in promoting myogenesis. , 1995). It is upregulated during the late phase of gestation and after birth to 8 weeks, after which it declines. This period coincides with muscle fiber hypertrophy. In tissue culture it is expressed from day 1 and the expression increases parallel with the accumulation of myotubes. The expression of SLIM precedes that of myogenin. Like other members of the LIM protein family (zyxin, paxillin, and CRP), SLIM may serve a role in the elaboration of muscle fiber matrix anchorage.

1992). , 1996a). , 1994). The pRB deficient myotubes could be induced by growth factors to reenter into the cell cycle, indicating that p107 could not maintain the terminally differentiated state against the mitogenic effect of growth factors. , 1993) and in the activation of satellite cells following muscle injury (Bischoff, 1994). , 1996). Therefore, some of the consequences of pRb deficiency may be moderated by increased degradation of E2F1. REGULATION OF THE ACTIVITY OF EARLY GENES BY GROWTH FACTORS Several early genes (Id, c-fos, c-jun, c-myc) whose products inhibit muscle differentiation Transcriptional regulation of gene expression 35 are induced in proliferating myoblasts or when quiescent cells are stimulated by growth factors.

Download PDF sample

Rated 4.84 of 5 – based on 47 votes