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By Ronald Aylmer Fisher

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1999 No association Mann et al. 2008 Choi et al. 2010 Kwang-Yeon et al. 2010 Serretti et al. 2011 Significant association Kishi et al. 2011 Kishi et al. 2012 (meta-analysis) Genes of the serotonergic system Tyrosine hydroxylase is responsibe for the first and rate-limiting step in synthesis of catecholamines (it converts tyrosine into Ldopa) Gene function decarboxylated to form serotonin. TPH2 is an isoform of TPH that is expressed in the brain. 1 Gene HTR2C HTR3A HTR3B HTR4 HTR5A G-protein coupled multi-pass membrane protein, which functions in part through the regulation of intracellular Ca2+ mobilization.

This results in trisomy or monosomy. However, the whole set of chromosomes can be as well either doubled or tripled [Buselmaier 2004]. 6 Methods of Molecular Bipolar Disorder Research Association Studies Association studies are important methods to investigate complex traits, for example bipolar disorder. This method detects smaller effect sizes much better than linkage studies. Association studies are usually performed as a case-control design. They search for association between an allele marker and disease within a population, which cannot occur only by chance.

2009]. HTR1A knockout mice show anxiety like behavior and avoid stressful situations [Parks et al. 1998; Ramboz et 60 al. 1998; Gross et al. 2002]. PET studies showed higher raphe autoreceptor binding and thus decreased serotonergic neurotransmission in affective disorder [Sullivan et al. 2009]. Promoter Polymorphism -1019C/G (rs6295) The promoter polymorphism -1019C/G (rs6295), leading to a cytosine to guanine exchange at position -1019, blocks transcriptional repression and leads to increased autoreceptor expression.

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