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23 Applications of Polymers in Drug Delivery The bilayered tablets are formulated in four steps. First a tablet is made by compression of L-HPC and lactose or stearic acid (first layer), which is then compressed along with a mixture of the drug and crystalline cellulose (second layer). The bilayered tablet is then coated with a solution of EC and micropores are formed either mechanically or by laser on the first layer. Finally, tablets are sugar coated [50]. 3 Pressure Controlled System In the large intestine, the contents are moved from one part to the next, as from the ascending to the slanting colon by forcible peristaltic movements commonly termed as mass peristalsis [51].

For rapid release of water insoluble drug effervescent or disintegrating agents are added. , polymethacrylates). , HPMC, PVA). , glyceryl monooleate). , pectin). 3 Ion-Exchange Based Drug Delivery System Ion exchange resins are insoluble polymers that contain acidic or basic functional groups and have the ability to exchange counter-ions within aqueous solutions surrounding them. An ion exchange resin is an insoluble matrix normally in the form of small beads of 1-2 mm diameter, usually white or yellowish, fabricated from an organic polymer substrate backbone [54].

A mathematical model for drug release properties of polymer coated ion-exchange resin complex has also been derived. For example, polymer (polyvinyl acetate) 25 Applications of Polymers in Drug Delivery coated dextromethorphan-resin complexes have been explored for studying release characteristics by considering diffusion, swelling, and ion exchange processes [57]. 2 Transdermal Drug Delivery System Research in the field of polymer science has paved the way for transdermal delivery system designs that have considerable flexibility.

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