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Extra info for Update on the Treatment of Chronic Viral Hepatitis - Gastroenterology Clinics of North America Vol 33 Issue 3

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The major predictor is genotype, with genotype 1 patients having a markedly reduced response (42% to 46%) compared with patients with genotypes 2 and 3 (76% to 82%). After genotype, multiple other factors have lesser predictive value but can still be clinically important when one is individualizing therapy. Clinically relevant predictors that indicate a more difficult-to-treat patient include viral load greater than 2 million by PCR test, presence of advanced fibrosis or cirrhosis, high body mass index, and African American race.

Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study. J Hepatol 1996; 25(5):591–8. [16] Bodenheimer HC Jr, Lindsay KL, Davis GL, Lewis JH, Thung SN, Seeff LB. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multi-center trial. Hepatology 1997;26(2):473–7. [17] Poynard T, Marcellin P, Lee SS, Niederau C, Minuk GS, Ideo G, et al. Randomised trial of interferon alpha-2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus.

Amsterdam (The Netherlands): CONGREX Holland BV; 1992. p. A3373. [85] Boyer NMP, Degott C, Degos F, Saimot AG, Erlinger S, Benhamou JP, et al. Recombinant interferon-a for chronic hepatitis C in patients positive for antibody to human immunodeficiency virus. J Infect Dis 1992;165:723–6. [86] De Sanctis GMEG, Barbacini IG, Bergami N, Chireu LV. Long-term outcome of chronic hepatitis infection in HIV þ subject treated with interferon. In: Programs and Abstracts of the 9th International Conference on AIDS; 1993.

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