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By F. Deinhardt (auth.), Dr. Francesco Callea, Professor Dr. Mario Zorzi, Professor Dr. Valeer J. Desmet (eds.)

The Brescia department of the Italian organization of Blood donors (AVIS­ Brescia) celebrated its fiftieth anniversary in 1985. the belief of organizing a Postgraduate direction on Viral Hepatitis in this party constructed for ob­ vious purposes. Viral hepatitis is a huge drawback in blood transfusion and Brescia is found within the quarter of Lombardy characterised via a excessive HBsAg provider cost in its inhabitants. hence it appeared well timed to convene a systematic discussion board within which the current country of information on viral hepatitis will be summarized. this may let us assessment the large growth completed during the last 15 years, and likewise to target most recent advancements which pave the best way for destiny research. The e-book of the complaints of this assembly was once thought of use­ ful, because it presents a tangible reminder of a finished assessment of the extensive subject of viral hepatitis, its problems, and its connections with the perform of blood transfusion. The organizers have been lucky in acquiring the energetic participation of well-known specialists in a number of hepatological diSCiplines. Their contri­ butions summarized the extra mature components of data within the box, in­ cluding medical elements, epidemiology and morphology, in addition to more recent advancements within the vanguard of hepatitis examine, like new diagnostic suggestions, oncogenesis, therapy, and vaccination.

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Gut 19: 510-513 Demeulenaere F, Desmet VJ, Dupont E, Fiasse R, Gisselbrecht H, Heully F, Jeanpierre R, Lecompte J, Lennes G, Macinot C, Migeotte P, Pirotte J, Rauber G, Ruyters L, Van Cauwenberge H (1981) Effects du (+)-cyanidanol-3 dans Ie trattement de l'hepatite chronique active. Gastroenterol Clin BioI 5: 314-323 Desmet VJ (1985) New aspects of piecemeal necrosis. In: Bianchi L, Gerok W, Popper H (eds) Trends in hepatology. J. Desmet: Histopathology of Chronic Viral Hepatitis Desmet VJ, De Vos R (1985) Ultrastructural fmdings in non-A, non-B viral hepatitis.

For this purpose, we have reviewed a series of liver biopsy specimens from 250 HBsAg-positive cases collected in the Department of Pathology of Brescia Hospital. 2 Immunohistochemical Detection of Viral Antigens in Liver Tissue Original work on tissue localization of HBV and delta antigens was carried out by the immunofluorescence technique (Coyne et al. 1970; Gudat et al. 1975; Rizzetto et al. 1977). Since then immunoperoxidase techniques have become largely available. The latter are more sensitive and permanent-staining techniques; moreover immunoperoxidase-stained sections can be counterstained with hematoxylin for the simultaneous evaluation of both viral antigens distribution and histological features.

Multilobular necrosis (Baggenstoss et al. 1972) affects several adjacent liver lobules, and apparently corresponds to CN in a whole acinar agglomerate (Rappaport 1976). The term bridging nepatic necrosis (BHN) has been proposed (Conn 1976; Boyer 1976) to indicate confluent necrosis linking portal tracts and central veins. BHN thus encompasses in increasing degree of severity portal-central confluent necrosis, panlobular, and multilobular necrosis. Regeneration of Liver Cells. Regeneration of liver cells may be reflected in various appearances: actual liver-cell mitoses; appearance of small basophilic liver cells at the edge of CN; appearance of double cell thick plates; nodular regeneration; and in some instances appearance of multinucleated parenchymal giant cells.

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