Download Viral Therapy of Human Cancers (Basic and Clinical Oncology) by Joseph G. Sinkovics, Joseph Horvath PDF

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By Joseph G. Sinkovics, Joseph Horvath

Surveys attainable learn pathways for the remedy of human cancers. Examines the regression of tumors in virally-infected sufferers, in addition to controversies all for viral oncolysis. Analyzes gene remedy and lively particular immunotherapy of human tumors through viral vectors.

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Extra resources for Viral Therapy of Human Cancers (Basic and Clinical Oncology)

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However, W. Cassel’s and V. Schirrmacher’s trials, taken together [122,227–230], indicate that NDV oncolysates as ‘‘preventive vaccines’’ perform very well against micrometastases left behind after surgical removal of gross tumors (melanoma and various adenocarcinomas). D. Anderson Hospital but using techniques different from those of W. Cassel, induced melanoma cell-specific antibodies in patients, but provided no significant protection against relapses; W. Cassel clarified the issue [231–233].

Schirrmacher (Chapter 4 in this volume) has used the incompletely replicating but cytokine- and immune- reactions–evoking Ulster strain of NDV for human tumor immunotherapy. Dendritic cells pulsed with Ulster NDV oncolysates induce Matzinger’s danger signals, re-enlist memory cells resting in the bone marrow, and react to tumor (breast cancer) antigens. Another German group used the Ulster strain of NDV to prepare glioblastoma vaccines for active tumor-spe- Progressive Development of Viral Therapy 45 cific immunotherapy given postresection and postradiotherapy [237].

Anderson Hospital symposium, these authors presented work on tumor cell xenogenization with viral gene transfers (Friend virus env gene; influenza A virus hemagglutinin gene) into tumor cells, rendering the tumor cells more antigenic in their hosts. At the European Association for Cancer Research symposium in Athens, Greece, in 1989, I reviewed this work in comparison with the Progressive Development of Viral Therapy 33 direct effect of oncolytic viruses [165]. Unfortunately, the Moloney mouse leukemia virus envelope protein, when expressed in the membranes of tumor cells, elicited the opposite effect in both allogeneic and syngeneic systems, whereby the tumor cells became immunosuppressive and evaded rejection [166].

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