By Eric Denkers
Utilizing as a topic the come across among protozoan parasites and macrophages, this quantity brings jointly mobile biologists, immunologists and protozoologists to study present advancements during this huge and dynamic learn region. mentioned are methods protozoans identify their intracellular area of interest, how they turn on macrophage effector features, what those services are, and potential during which a number of protozoans subvert macrophage job. What emerges is an image of the macrophage as a key mobile style within the host reaction to protozoan an infection. How those cells reply, and the way their responses should be subverted, usually are serious determinants within the consequence of protozoan an infection. thousands of lives are misplaced each year to protozoan infections, most significantly these brought on by Plasmodium, but in addition Trypanosoma and Leishmania spp. different protozoans, corresponding to Toxoplasma, are so exquisitely tailored to their host that they not often reason sickness, other than in the course of host immunodeficiency. we are hoping that by way of practicing an knowing of the biology of protozoans in macrophages we are going to finally be ready to treating and combating disorder and mortality brought on by this significant type of microbial pathogens.
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30,32,33 The process of gliding motility requires the coordinated activities of protein secretion and translocation via the actin-based cytoskeleton. Adhesion to the cell substrate and host cell receptors is largely mediated by microneme proteins,34 which are discharged apically from small secretory vesicles. 15 Apically discharged adhesins form contacts with the substrate or host cell surface. These adhesin complexes are translocated rearward by the underlying actin-myosin cytoskeleton, thus propelling the parasite forward.
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King CA. Cell motility of sporozoan protozoa. Parasitol Today 1988; 11:315-318. 14. Sibley LD. Invasion strategies of intracellular parasites. Science 2004; 304:248-253. 15. Håkansson S, Morisaki H, Heuser JE et al. Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion. Mol Biol Cell 1999; 10:3539-3547. 16. Barragan A, Sibley LD. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J Exp Med 2002; 195:1625-1633.