By Heinz Lother, Rudolf Dernick, Wolfram Ostertag
Utilizing the newest thoughts of molecular genetics it really is now attainable to review the mechanisms of telephone development and differentiation on the molecular point. specifically the appliance of viral vectors to imagine and examine gene expression, the thoughts of stem mobilephone manipulation in addition to numerous effects in regards to the functionality of oncogenes or the function of cytokines and development components are mentioned resulting in new interpretations of the mechanisms which bring about basic or irregular mobilephone differentiation.
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Extra info for Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation
In Fig. 1b, the histochemical staining obtained with such a fusion protein is illustrated. Its localization is mainly nuclear or perinuclear, and therefore allows the study of those cell types which possess endogenous activity. 35 FIG. 1. Detection of B-galactosidase actlVlty in a line of embryonal carcinoma cells infected with a LacZ recombinant retrovirus. a) Phase contrast. b) FDG labelling (the FDG has been introduced in the cells directly into the culture dish during a hypotonic shock; the enzymatic reaction has been followed for one hour), the clone is examined under UV illumination.
Dev BioI 124:125-133 Fienberg AA, Utset MF, Bogarad LD, Hart CP, Awgulewitsch A, Ferguson-Smith A, Fainsod A, Rabin M, Ruddle FH (1987) Homeobox genes in murine development. Curr Top Dev BioI 23:233-256 30 Finney M, Ruvkun G, Horvitz HR (1988) The C. elegans cell lineage and differentiation gene ~ encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 55:757-769 Frigerio G, Burri M, Bopp D, Baumgartner S, Noll M (1986) Structure of the segmentation gene ~ and the Drosophila PRD gene set as part of a gene network.
1987; 1989); (2) the pattern of expression of a "ubiquitous" promoter linked to nlsLacZ during embryogenesis; (3) the detection of a region in the genome of multipotential cells that complements a defective promoter. These three approaches represent different ways of gathering information on the modulation of gene expression during embryogenesis. The data presented indicate that the transcriptional machinery has an unusual specificity during early embryogenesis and that a transcriptional unit may be treated differently depending on whether it has been delivered directly to the cell or introduced into the genome as a heritable marker in transgenic mice.